The Duke and Duchess of Cambridge will be visiting Sutton next week.
William and Kate will be making one of their first official engagements since their marriage in April at the Royal Marsden Hospital on Thursday, September 29.
The royal couple are opening the Marsden's new specialist children's cancer treatment ward, the Oak Centre for Children and Young People.
Hundreds of residents are expected to try and catch a glimpse of the newly-weds as they arrive at the hospital.
The couple will then be given a tour of the new children’s centre, where they will meet staff and patients.
The Duke will also be invited to unveil a plaque to officially open the centre before he and the Duchess meet patients, hospital staff and key donors and fundraisers.
The hospital's chief executive, Cally Palmer, said: "We are delighted that Their Royal Highnesses The Duke and the Duchess of Cambridge have chosen to officially open the new Oak Centre for Children and Young People at The Royal Marsden as one of their very few official engagements since their wedding in April.
"The Duke of Cambridge’s relationship with the hospital and the charity is testament to how highly he views the work of The Royal Marsden, its staff, patients and supporters, and how seriously he takes his role as our president."
Prince William became the cancer hospital's president in May 2007 having undertaken two days of work experience there in 2005.
The position was previously held by his mother, Diana, Princess of Wales.
Cally Palmer was invited to the Duke and Duchess's wedding at Westminster Abbey in April.
The Oak Centre that the couple will be opening is one of the largest comprehensive children's cancer centres in Europe, with 31 beds.
It will see almost 600 inpatients and more than 5,000 day patients every year.
The £18m cost of building it was raised by the Royal Marsden Cancer Charity and Teenage Cancer Trust.
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