Harlequins scrum-half Andy Gomarsall has failed to shake off a back injury in time to face France in the Six Nations on Saturday.
Sale Sharks youngster Richard Wigglesworth takes his place in the England line-up in Paris at the weekend, while there is a place on the bench for former Sutton & Epsom youngster Paul Hodgson.
Quins number eight Nick Easter, who passed a late fitness test to play in his club's Guinness Premiership triumph over Worcester Warriors on Saturday, retains his place in the starting XV.
The team is as follows: 15 Iain Balshaw (Gloucester Rugby) 14 Paul Sackey (London Wasps) 13 Jamie Noon (Newcastle Falcons) 12 Toby Flood (Newcastle Falcons) 11 Lesley Vainikolo (Gloucester Rugby) 10 Jonny Wilkinson (Newcastle Falcons) 9 Richard Wigglesworth (Sale Sharks) 1 Andrew Sheridan (Sale Sharks) 2 Mark Regan (Bristol Rugby) 3 Phil Vickery (London Wasps, captain) 4 Simon Shaw (London Wasps) 5 Steve Borthwick (Bath Rugby) 6 James Haskell (London Wasps) 7 Michael Lipman (Bath Rugby) 8 Nick Easter (Harelquins) Replacements 16 Lee Mears (Bath Rugby) 17 Matt Stevens (Bath Rugby) 18 Ben Kay (Leicester Tigers) 19 Tom Croft (Leicester Tigers)* 20 Paul Hodgson (London Irish)* 21 Danny Cipriani (London Wasps) 22 Mathew Tait (Newcastle Falcons)
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